Ketamine: What to know about the sedative drug

Known as special K, key and K, ketamine is both a psychoactive club drug similar to acid or ecstasy and a promising option for treating depression or substance use disorder.

This story was originally published on PolitiFact.com.

With its dueling profile, the anesthetic ketamine has made lots of headlines in recent years.

It was scrutinized for its role in “Friends” actor Matthew Perry’s 2023 death. During the 2024 election, billionaire and business owner Elon Musk said he used ketamine to treat depression while others reported he may have misused it.

Now, a former Cornell University student’s lawsuit alleging she was gang raped by a group of fraternity members in 2024 includes numerous descriptions of ketamine use by her and her attackers.

As recreational ketamine use rises and researchers continue to explore ways the drug could help people in clinical settings, here’s a primer on this drug, its uses and its risks.

What is ketamine?

It is a dissociative drug, meaning it makes users feel detached from their body, pain and the physical environment, according to the Drug Enforcement Administration. It can also cause hallucinations and sedation.

The Food and Drug Administration approves of ketamine for anesthesia purposes, as it can help block pain and cause unconsciousness. For this purpose, it is typically administered intravenously or injected into a muscle.

The FDA has also approved the nasal spray esketamine, a ketamine derivative, to treat depression in very controlled circumstances.

Under federal law, ketamine is classified a Schedule III drug, which means it has a “moderate to low” potential for physical and psychological dependence and less potential for abuse than Schedule II drugs such as cocaine and methamphetamine.

It has a reputation as a party, club and rave drug. Its other nicknames include ket, super K, vitamin K or super acid. Liquid ketamine is injected, mixed into drinks or evaporated into crystals that are then ground into powder that can be snorted or smoked. It has been used to facilitate sexual assault.

Ketamine is legal with a prescription for medical use, including for off-label uses such as treatment for post-traumatic stress disorder.

But its status as a Schedule III drug means that it is illegal to possess and distribute or traffic ketamine for recreational use.

What is ketamine used for in clinical settings?

Before and during a surgical procedure, it can be used at high doses to cause drowsiness, promote sleep and render a person unconscious.

Esketamine, sometimes also simply called ketamine, is used to manage depression that’s unresponsive to other treatments and can offer rapid relief. The spray is administered in a hospital or clinic and healthcare providers monitor patients for at least two hours before they are allowed to leave.

Ketamine therapy is when medical professionals administer low doses of the drug. Some people describe esketamine spray for depression as ketamine therapy, but the term also refers to doctors prescribing ketamine infusions off-label to treat conditions such as chronic pain, depression, obsessive compulsive disorder and PTSD. Medication being prescribed “off-label” means it isn’t FDA approved for that purpose.

Early research has also found short-term benefits to using ketamine as a substance use disorder treatment, but more research is needed.

How is ketamine misused or abused?

The drug is sometimes used recreationally because it can cause an out-of-body experience or produce hallucinations that last about 30 minutes to a few hours. Some people describe a dissociative state or experiencing oblivion, sometimes called a “k-hole.”

Ketamine can cause immobility, sedation, amnesia and distort a person’s sense of sight and smell. Overdosing on ketamine can cause unconsciousness and dangerously slowed breathing.

What are side effects and other risks of ketamine?

Side effects can include headache, dizziness, nausea, blurred vision, poor memory, confusion, anxiety, agitation, a spike in blood pressure and shortness of breath.

People can develop an addiction to ketamine, and that risk is higher for people who have a history of addiction.

Long-term ketamine abuse also carries risks such as poor memory and concentration, abnormal liver or kidney function and ketamine bladder syndrome (weakened bladder, incontinence and bladder ulceration), according to the Alcohol and Drug Foundation in Australia.

How does it mix with alcohol?

As a central nervous system depressant, alcohol slows brain activity. Mixing alcohol with ketamine increases the sedative effects of both drugs, increasing a person’s risk of losing consciousness.

At lower doses of combining the two, a person risks nausea and vomiting and at higher doses the risk of passing out and then aspirating vomit increases.

“Even on relatively small doses, you’re very detached from things,” New York University ketamine researcher Joseph Palamar told The New York Times. “You’re not as in touch with your emotions.” As the dose increases, it becomes harder to communicate, he said.

This story was originally published on PolitiFact.com.

It is republished here as part of a reporting and fact-checking partnership between PolitiFact and Hearst Television.